Adenosine Metabolism in Human Erythrocytes
ثبت نشده
چکیده
منابع مشابه
MODULATION OF MITOCHONDRIAL UPTAKE OF A DENOSINE BY NITROBENZYLTHIOINOSINE
In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mito...
متن کاملHypoxanthine production from nucleosides in erythrocyte ghosts.
A primary event in the metabolism of nucleosides by human erythrocytes involves the action of a nucleoside phosphorylase (l-3). In the presence of arsenate, free ribose is produced from adenosine, inosine, guanosine, and xanthosine (4). Adenosine has been reported to be converted to adenine (4), but other studies have shown that adenosine was converted by deamination to inosine and then cleaved...
متن کاملEffect of alkali-treated lipopolysaccharide on the intracellular cations of human erythrocytes.
The adsorption to human erythrocytes of Escherichia coli lipopolysaccharide treated by mild alkaline hydrolysis (h-LPS) stimulated an increase in the intracellular Na+ concentration and a decrease in the intracellular K+ concentration of the erythrocytes. Erythrocytes treated by h-LPS remained responsive to the membrane adenosine triphosphatase inhibitors ouabain and ethacrynic acid, indicating...
متن کاملStudies on the metabolism of adenosine and adenine in stored and fresh human erythrocytes.
By BERTRAM A. Lowi’ AND MARJORIE K. WILLIAMS T HE MATURE human erythrocyte, which is incapable of de novo purine nucleotide synthesis, can utilize preformed purines and purine nucleosides for tile formation of purine nucleotides, in vitro.” 2 Studies in this laboratory have demonstrated that adenine is an effective precursor of the ATP of the human erythrocyte and that hypoxanthine, guanine, an...
متن کاملChanges in Adenosine Metabolism in Asthma. A Study on Adenosine, 5ʹ-NT, Adenosine Deaminase and Its Isoenzyme Levels in Serum, Lymphocytes and Erythrocytes
Background: Adenosine deaminase (ADA) and 5ʹ-nucleotidase (5ʹ-NT) play a crucial role in adenosine metabolism in healthy individuals. Adenosine is an inflammatory mediator of asthma. Changes in adenosine metabolism and role of ADA and 5ʹ-NT in regulating adenosine level in asthmatics and correlation of these changes with severity of asthma are not clearly understood. Methods: In this study, we ...
متن کامل